Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations

Figure 3

MRM chromatograms and the plasma concentration-time profiles of notoginsenoside R₁, Rg₁, and Rb₁ in rats following intragastric administration of different sizes of PNP at a dose of 540 mg/kg. A: blank rat plasma, B: blank plasma spiked with notoginsenosides and IS, C: rat plasma collected at 30 min after intragastric administration of 540 mg/kg PNP. a, d: notoginsenoside R₁; b, e: ginsenosides Rg₁; c, f: ginsenosides Rb₁. Samples 1 ∼ 6 correspond to Powders 1 ∼ 6, and 30, 40, 50, and 100°C correspond to the PNP treated at different hydrothermal temperatures.