Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations

Table 4

The pharmacokinetic parameters of notoginsenosides following the intragastric administration of 540 mg/kg PNP (n = 6)

Notoginsenoside	Sample	Cmax (ng/mL)	Tmax (h)	t1/2 (h)	MRT (h)	AUC0-T (ng·h/mL)	AUC0-∞ (ng·h/mL)
R1	1	96.77 ± 8.33	0.75 ± 0.43	61.40 ± 24.40	24.39 ± 0.28	3927.74 ± 168.19	15934.90 ± 3756.68
	2	214.85 ± 46.16	18.67 ± 8.64	30.85 ± 17.86	25.56 ± 1.18	7988.59 ± 1539.43	22347.20 ± 3962.25
	3	480.12 ± 184.33	1.31 ± 0.91	45.18 ± 19.94	23.28 ± 1.62	10703.32 ± 195.88	26067.99 ± 2653.31
	4	2520.17 ± 699.78	1.83 ± 1.68	10.83 ± 5.83	20.42 ± 0.76	24392.12 ± 1209.31	25608.71 ± 963.71
	5	1325 ± 70.20	0.15 ± 0.03	11.01 ± 0.13	10.58 ± 0.19	5136.15 ± 139.26	6490.01 ± 2116.24
	6	585.16 ± 113.86	0.92 ± 0.30	58.53 ± 29.21	16.55 ± 1.66	1832.64 ± 147.30	4246.85 ± 1457.93
Rg1	1	1078.91 ± 221.73	0.43 ± 0.15	22.28 ± 17.71	13.64 ± 1.25	14876.10 ± 3408.79	44835.03 ± 14993.19
	2	1997.5 ± 325.40	0.96 ± 0.10	17.02 ± 3.81	19.36 ± 2.01	33292.35 ± 6663.89	58485.02 ± 38882.91
	3	1577.33 ± 8.17	1.17 ± 0.41	57.43 ± 24.07	23.30 ± 2.23	26219.02 ± 2116.79	73657.82 ± 31451.60
	4	10134.52 ± 4812.27	1.83 ± 1.68	7.72 ± 0.83	23.04 ± 1.70	84696.89 ± 13040.28	85766.94 ± 12948.66
	5	10590 ± 230.56	0.29 ± 0.10	3.52 ± 0.72	8.72 ± 0.38	23225.07 ± 2017.82	23433.90 ± 1935.81
	6	2270.72 ± 670.85	1.04 ± 0.25	5.78 ± 1.29	4.7 ± 0.36	5396.88 ± 349.55	5763.17 ± 335.36
Rb1	1	9.84 ± 4.99	36 ± 13.14	42.00 ± 24.07	28.69 ± 3.80	296.79 ± 85.85	770.01 ± 225.94
	2	64.52 ± 27.33	22.00 ± 4.90	11.17 ± 5.32	29.65 ± 0.73	1756.56 ± 634.27	2115.94 ± 361.33
	3	76.90 ± 9.97	18.00 ± 8.49	83.46 ± 52.21	22.57 ± 1.00	2444.21 ± 100.46	7518.63 ± 3769.97
	4	741.18 ± 408.39	2.05 ± 1.78	12.37 ± 7.81	18.33 ± 1.17	7212.91 ± 169.41	10109.07 ± 4381.42
	5	331.05 ± 16.35	0.15 ± 0.03	10.85 ± 2.52	11.50 ± 0.32	2031.16 ± 61.08	2160.99 ± 71.61
	6	140.71 ± 21.88	0.79 ± 0.37	56.67 ± 31.54	18.56 ± 1.29	1068.46 ± 179.46	2388.17 ± 841.41

Samples 1 ∼ 6 correspond to Powders 1 ∼ 6., versus Powder 6.