Aidi Injection as Adjuvant Drug Combined with Chemotherapy in Treatment of Breast Cancer: A Systematic Meta-Analysis

Table 2

Summary of comparisons of ADRs among the patients receiving chemotherapy alone and chemotherapy plus Aidi injection.

ADRs	Number of studies	Number of patients	Heterogeneity (/I^2)	Model	OR
Myelosuppression	7	486	0.80/0%	Fixed	0.34 [0.200, 55]	<0.0001
III-IV myelosuppression	4	259	0.25/28%	Fixed	0.43 [0.25, 0.76]	0.003
Digestive tract reaction	8	623	0.72/0%	Fixed	0.50 [0.33, 0.76]	0.001
III-IV digestive tract reaction	4	269	0.06/59%	Random	0.42 [0.22, 0.80]	0.008
Liver dysfunction	5	432	0.80/0%	Fixed	0.90 [0.48, 1.68]	0.74
III-IV liver dysfunction	1	96	NA	NA	0.48 [0.08, 2.74]	0.41
Leukocyte decrease	3	152	0.41/0%	Fixed	0.43 [0.19, 0.97]	0.04
III-IV leukocyte decrease	4	313	0.03/67%	Random	0.40 [0.24, 0.66]	0.0003
Hair loss	1	88	NA	NA	0.78 [0.30, 2.07]	0.62
III-IV hair loss	1	96	NA	NA	0.71 [0.23, 2.24]	0.56
Phlebitis	2	132	0.61/0%	Fixed	0.89 [0.40, 1.96]	0.77
II-IV cardiac function abnormality	4	320	0.78/0%	Fixed	0.16 [0.13, 0.38]	<0.00001
Atrial dysrhythmia	3	272	0.56/0%	Fixed	0.24 [0.13, 0.45]	<0.00001
Ventricular arrhythmia	3	272	0.96/0%	Fixed	0.08 [0.01, 0.42]	0.003
Atrioventricular block	3	272	0.94/0%	Fixed	0.29 [0.05, 1.80]	0.18
ST segment T wave inversion	3	272	0.91/0%	Fixed	0.25 [0.15, 0.42]	<0.00001
Abnormal ECG	3	272	0.80/0%	Fixed	0.17 [0.06, 0.47]	<0.00001

NA = not applicable; ADRs = adverse drug reactions; OR = odds ratio; ECG = electrocardiogram.