Review Article
Aidi Injection as Adjuvant Drug Combined with Chemotherapy in Treatment of Breast Cancer: A Systematic Meta-Analysis
Table 2
Summary of comparisons of ADRs among the patients receiving chemotherapy alone and chemotherapy plus Aidi injection.
| ADRs | Number of studies | Number of patients | Heterogeneity (/I2) | Model | OR | |
| Myelosuppression | 7 | 486 | 0.80/0% | Fixed | 0.34 [0.200, 55] | <0.0001 | III-IV myelosuppression | 4 | 259 | 0.25/28% | Fixed | 0.43 [0.25, 0.76] | 0.003 | Digestive tract reaction | 8 | 623 | 0.72/0% | Fixed | 0.50 [0.33, 0.76] | 0.001 | III-IV digestive tract reaction | 4 | 269 | 0.06/59% | Random | 0.42 [0.22, 0.80] | 0.008 | Liver dysfunction | 5 | 432 | 0.80/0% | Fixed | 0.90 [0.48, 1.68] | 0.74 | III-IV liver dysfunction | 1 | 96 | NA | NA | 0.48 [0.08, 2.74] | 0.41 | Leukocyte decrease | 3 | 152 | 0.41/0% | Fixed | 0.43 [0.19, 0.97] | 0.04 | III-IV leukocyte decrease | 4 | 313 | 0.03/67% | Random | 0.40 [0.24, 0.66] | 0.0003 | Hair loss | 1 | 88 | NA | NA | 0.78 [0.30, 2.07] | 0.62 | III-IV hair loss | 1 | 96 | NA | NA | 0.71 [0.23, 2.24] | 0.56 | Phlebitis | 2 | 132 | 0.61/0% | Fixed | 0.89 [0.40, 1.96] | 0.77 | II-IV cardiac function abnormality | 4 | 320 | 0.78/0% | Fixed | 0.16 [0.13, 0.38] | <0.00001 | Atrial dysrhythmia | 3 | 272 | 0.56/0% | Fixed | 0.24 [0.13, 0.45] | <0.00001 | Ventricular arrhythmia | 3 | 272 | 0.96/0% | Fixed | 0.08 [0.01, 0.42] | 0.003 | Atrioventricular block | 3 | 272 | 0.94/0% | Fixed | 0.29 [0.05, 1.80] | 0.18 | ST segment T wave inversion | 3 | 272 | 0.91/0% | Fixed | 0.25 [0.15, 0.42] | <0.00001 | Abnormal ECG | 3 | 272 | 0.80/0% | Fixed | 0.17 [0.06, 0.47] | <0.00001 |
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NA = not applicable; ADRs = adverse drug reactions; OR = odds ratio; ECG = electrocardiogram.
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