Metabolomic Study on the Therapeutic Effect of the Jianpi Yangzheng Xiaozheng Decoction on Gastric Cancer Treated with Chemotherapy Based on GC-TOFMS Analysis

Table 3

Different metabolites between two groups.

No.	Class	Name	C vs A				B vs A
			VIP^a	FC^b		Tendency^d	FC	P	Tendency
1	Amino acid	L-Cysteine	2.5	1.667	<0.001	↑^#	1.123	0.959	↑
2	Carbohydrates	Gluconolactone	2.4	0.656	0.0018	↓^#	0.761	0.038	↓
3	Amino acid	Creatinine	2.2	1.371	0.0039	↑^#	0.946	0.878	↓
4	Lipids	Glycerol 3-phosphate	2.2	1.946	0.0045	↑^#	1.603	0.959	↑
5	Amino acid	L-Cystine	2.3	2.461	0.0059	↑^#	1.307	0.279	↑
6	Amino acid	L-Tryptophan	2.3	1.692	0.0065	↑^#	0.923	0.959	↓
7	Amino acid	L-Glutamine	2.1	1.429	0.0067	↑^#	1.141	0.721	↑
8	Amino acid	L-Lysine	2.2	1.301	0.0096	↑^#	0.992	0.959	↓
9	Amino acid	Aminomalonic acid	2	0.765	0.01	↓	1.075	0.721	↑
10	Amino acid	Ketoleucine	2.1	1.701	0.012	↑	0.708	0.382	↓
11	Amino acid	L-Methionine	2.1	1.335	0.014	↑	1.074	0.959	↑
12	Vitamin	Alpha-Tocopherol	2.1	2.843	0.016	↑	0.916	0.959	↓
13	Amino acid	Ratio of L-glutamine/L-glutamic acid	2.0	2.478	0.016	↑	1.497	0.878	↑
14	Organic acids	Pyruvic acid	1.9	3.82	0.017	↑	0.949	0.878	↓
15	Amino acid	Ratio of pyruvic acid/L-alanine	1.9	3.643	0.018	↑	0.995	1.000	↓
16	Amino acid	Ratio of L-glutamic acid/L-glutamine	2.1	0.402	0.020	↓	0.693	0.878	↓
17	Amino acid	Alpha-Ketoisovaleric acid	1.9	1.785	0.024	↑	0.901	0.878	↓
18	Amino acid	Ratio of L-tyrosine/L-phenylalanine	1.8	1.343	0.027	↑	0.965	0.721	↓
19	Amino acid	Ratio of beta-alanine/L-aspartic acid	1.8	1.339	0.029	↑	1.37	0.382	↑
20	Amino acid	L-Tyrosine	1.7	1.165	0.033	↑	0.785	0.798	↓
21	Amino acid	L-Alpha-aminobutyric acid	1.7	1.121	0.041	↑	0.736	0.442	↓
22	Amino acid	2-Hydroxybutyric acid	1.7	1.459	0.042	↑	1.08	1.000	↑
23	Lipids	MG181	1.7	1.92	0.042	↑	0.948	1.000	↑
24	Amino acid	L-Leucine	1.7	1.406	0.045	↑	1.439	0.083	↑
25	Amino acid	Ratio of L-glutamic acid/oxoglutaric acid	1.7	0.543	0.045	↓	1.031	1.000	↑
26	Amino acid	Acetyl glycine	1.7	0.752	0.046	↓	1.073	0.721	↑
27	Amino acid	L-Alloisoleucine	1.7	—	0.042	↑	1.5	0.021	↑
28	Amino acid	L-Valine	1.6	1.293	0.064	↑	1.222	0.328	↑
29	Amino acid	Ratio of citrulline/L-arginine	—	0.981	0.584	↓	0.786	0.0011	↓^#
30	Amino acid	L-Homoserine	—	1.096	0.739	↑	1.853	0.003	↑^#
31	Hormone	Normetanephrine	—	1.185	0.603	↑	2.038	0.010	↑
32	Fatty acids	Behenic acid		0.776	0.293	↓	0.582	0.015	↓
34	Amino acid	Ratio of L-serine/glycine	—	1.117	0.842	↑	2.374	0.021	↑
35	Amino acid	Ratio of glycine/L-serine		0.895	0.970	↓	0.426	0.021	↓
36	Amino acid	Ratio of citrulline/ornithine	1.5	0.82	0.083	↓	0.76	0.021	↓
37	Organic acids	3-Methyl-2-oxovaleric acid	—	1.091	0.410	↑	0.83	0.024	↓
38	Lipids	Decanoylcarnitine	1	0.627	0.200	↓	0.534	0.028	↓
39	Amino acid	Glycine	—	1.082	0.920	↑	0.656	0.038	↓
40	Amino acid	Ratio of ketoleucine/L-leucine	—	1.249	0.471	↑	0.736	0.050	↓

^aVIP values were obtained from cross-validated OPLS-DA models with a threshold of 1. ^bFold change was calculated as the ratio of the mean metabolite levels between two groups. ^c values were calculated from two-tailed student’s T-test or Mann–Whitney U test or with a threshold of 0.05 and 0.01. ^d↑, content increased; ↓, content decreased; ^#Compared with group A,  < 0.01; Compared with group A,  < 0.05.