Pathway name Impact Down# Up# Valine, leucine, and isoleucine biosynthesis <0.001 0.75 Alpha-Ketoisovaleric acid; ketoleucine; L-leucine; L-threonine; L-valine — Arginine biosynthesis <0.001 0.31 L-Glutamine; urea Citrulline; L-aspartic acid; L-glutamic acid Cysteine and methionine metabolism <0.001 0.24 L-Alpha-aminobutyric acid; L-cysteine; L-cystine; L-methionine; pyruvic acid Homocysteine Histidine metabolism 0.00183 0.33 1-Methylhistidine; L-histidine L-Aspartic acid; L-glutamic acid Alanine, aspartate, and glutamate metabolism 0.00283 0.48 L-Glutamine; pyruvic acid L-Asparagine; L-aspartic acid; L-glutamic acid Pantothenate and CoA biosynthesis 0.0036 0.17 Alpha-Ketoisovaleric acid; L-cysteine; L-valine L-Aspartic acid D-Glutamine and D-glutamate metabolism 10.0114 0.67 L-Glutamine L-Glutamic acid Nitrogen metabolism 0.0167 0.25 L-Glutamine L-Glutamic acid Glyoxylate and dicarboxylate metabolism 0.0214 0.08 L-Glutamine; pyruvic acid Glycolic acid; L-glutamic acid Glycine, serine, and threonine metabolism 0.0264 0.05 Dimethylglycine; L-cysteine; L-threonine; pyruvic acid — Beta-Alanine metabolism 0.0351 0.05 L-Histidine L-Aspartic acid; spermidine Arginine and proline metabolism 0.0418 0.10 L-Proline; pyruvic acid L-Glutamic acid; spermidine Valine, leucine, and isoleucine degradation 0.0492 0.08 Alpha-Ketoisovaleric acid; ketoleucine; L-leucine; L-valine —
