Efficacy and Safety of Banxia Formulae for Insomnia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Table 1

Basic characteristics of the included studies.

Included trials treatment	Publication language	No. of participants (male/female; age years)		Treatment		Outcome index	Duration	Intergroup difference
		Experimental	Control	Experimental	Control
Chen 2019 [20]	Chinese	25/15; 38.8	23/17; 38.6	Huanglian wendan decoction	Tranquillizer	(1) Total effective rate	20 d	(1)
						(4) Adverse event(s)		(4)
Ding 2014 [21]	Chinese	12/18; 62.5	13/17; 63.5	Wendan decoction	Tranquillizer	(1) Total effective rate	28 d	(1)
Fei 2018 [22]	Chinese	8/18; 40.62	6/14; 41.05	Chaihu wendan decoction	Estazolam	(1) Total effective rate	4 w	(1)
						(2) PSQI total score		(2)
						(3) TCM syndrome score		(3)
						(4) Adverse event(s)		(4)
Fu 2018 [23]	Chinese	10/17; 57.33	8/18; 55.08	Banxia Shumi decoction	Estazolam	(1) Total effective rate	3 w	(1)
						(2) PSQI total score		(2)
						(3) TCM syndrome score		(3)
						(4) Adverse event(s)		(4)
Guo 2016 [24]	Chinese	17/13; 42.33	14/16; 40.43	Banxia Shumi decoction	Zopiclone	(1) Total effective rate	21 d	(1)
						(2) PSQI total score		(2)
						(3) TCM syndrome score		(3)
						(4) Adverse event(s)		(4)
Huang 2013 [25]	Chinese	15/5; 36.82	10/10; 41.16	Wendan decoction	Tranquillizer	(1) Total effective rate	20 d	(1)
						(4) Adverse event(s)		(4)
Liu 2018 [26]	Chinese	14/16; 52.43	13/17; 51.57	Banxia Xiexin decoction	Alprazolam	(1) Total effective rate	4 w	(1)
						(2) PSQI total score		(2)
						(4) Adverse event(s)		(4)
Wang 2012 [27]	Chinese	34/28; 68.4	24/26; 69.6	Huoxue Huayu Tongluo decoction	Estazolam	(1) Total effective rate	30 d	(1)
Yin 2018 [28]	Chinese	14/16; 24.74	14/16; 24.33	Banxia Xiexin decoction	Estazolam	(1) Total effective rate	21 d	(1)
						(2) PSQI total score		(2)
						(3) TCM syndrome score		(3)
Zhang 2012 [29]	Chinese	21/39; 19–65	10/20; 18–63	Banxia formula	Tranquillizer	(1) Total effective rate	4 w	(1)
Zhang 2013 [30]	Chinese	16/23; 23–65	17/24; 22–64	Anshen Huatan decoction	Estazolam	(1) Total effective rate	4 w	(1)
Zhang 2017 [31]	Chinese	15/13; 59	12/12; 48	Banxia Shumi decoction and Huanglian wendan decoction	Alprazolam	(1) Total effective rate	2 w	(1)
						(4) Adverse event(s)		(4)
Zhang 2019 [32]	Chinese	8/21; 49.38	6/22; 44.21	Banxia Xinxie decoction and Huanglian wendan decoction	Lorazepam	(1) Total effective rate	4 w	(1)
						(2) PSQI total score		(2)
						(3) TCM syndrome score		(3)
						(4) Adverse event(s)		(4)
Zheng 2016 [33]	Chinese	9/21; 40.13	12/18; 38.25	Banxia Shumi decoction	Tranquillizer	(1) Total effective rate	7 d	(1)

PSQI, Pittsburgh Sleep Quality Index.