Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of Andrographis paniculata in Animal Models
Table 5
Antipyretic activity of AS201-01 tablet in yeast-induced pyrexia in rats.
Group (mg/kg)
Rectal temperature (°C)
Normal
Initial temperature (after 18 h)
After treatment
1 h
2 h
3 h
4 h
Negative control
36.48 ± 0.28
38.48 ± 0.22
38.16 ± 0.19
38.18 ± 0.19
38.32 ± 0.15
38.36 ± 0.19
AS201-01 tablet at dose 12.5
36.16 ± 0.14
37.78 ± 0.15
38.14 ± 0.19
37.62 ± 0.22
37.68 ± 0.32
37.62 ± 0.33
AS201-01 tablet at dose 25
36.20 ± 0.09
37.62 ± 0.21
37.22 ± 0.08
37.46 ± 0.17
37.36 ± 0.12
37.46 ± 0.07
AS201-01 tablet at dose 50
36.36 ± 0.09
38.06 ± 0.15
37.36 ± 0.31
36.92 ± 0.31
36.80 ± 0.39
37.36 ± 0.24
AS201-01 tablet at dose 100
36.30 ± 0.19
38.10 ± 0.10
37.26 ± 0.18
36.66 ± 0.17
36.22 ± 0.10
36.98 ± 0.24
Paracetamol at dose 150
36.68 ± 0.13
37.94 ± 0.21
36.72 ± 0.31
36.64 ± 0.27
37.16 ± 0.14
37.56 ± 0.25
Data are reported as mean ± SEM (n = 5). The data were analyzed by ANOVA followed by Dunnett’s test. Asterisks () indicate statistically significant value compared to the negative control, ;; and .
