Danggui Buxue Decoction Ameliorates Inflammatory Bowel Disease by Improving Inflammation and Rebuilding Intestinal Mucosal Barrier

Figure 1

DGBX can effectively prevent the occurrence of DSS-induced IBD. (a) Schematic of DSS modeling and drug administration, with 2.5% DSS treatment for 7 d with ordinary water as the normal control. The DGBX decoction or normal saline was fed intragastrically at 0.4 ml/day on day 0 for 8 d; the mice were killed and analyzed on day 9. Changes in the bodyweight (b) and colon length of the mice (c, d) in the control group (n = 6), DSS group (n = 7), and DSS + DGBX group (n = 7). (e) Hematoxylin and eosin staining of the distal colon sections and corresponding histological scores 9 days after DSS induction (n = 6 per group). The black asterisk denotes the comparison between the DSS + DGBX group and the DSS group, and the blue asterisk denotes the comparison between the DSS group and the control group. . Data are representative of three independent experiments, analyzed using the two-tailed unpaired t-test. Bar graphs denote the mean ± standard error of the mean (s.e.m.).

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