A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: The KOSMOS Study

Table 2

Changes of scores in the modified questionnaire for climacteric symptoms in Japanese women (placebo nonresponder group).

Mean changes of scores in the modified questionnaire for climacteric symptoms in Japanese women	Placebo nonresponder (NR)
	TJ-24 (n = 20)	Placebo (n = 20)	value
Excitability and irritability	−3.1 ± 1.7	−2.7 ± 2.2	0.519
Hot flashes	−1.9 ± 2.4	−1.9 ± 3.0	0.816
Sweating	−1.6 ± 2.7	−1.6 ± 2.9	0.989
Difficulty in sleeping	−1.9 ± 2.1	−1.9 ± 2.3	0.923
Waking up at night	−1.2 ± 2.8	−1.8 ± 2.5	0.595

Data are the mean changes from baseline of climacteric symptoms at week 12 in the placebo nonresponder group.