A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: The KOSMOS Study
Table 3
Subgroup analysis of changes of scores in the modified questionnaire for climacteric symptoms in Japanese women (placebo nonresponder group).
Mean changes of scores in the modified questionnaire for climacteric symptoms in Japanese women
Premenopausal
Postmenopausal
TJ-24 (n = 11)
Placebo (n = 11)
value
TJ-24 (n = 9)
Placebo (n = 9)
value
Excitability and irritability
−3.6 ± 1.5
−2.2 ± 2.1
0.046
−2.3 ± 1.7
−3.2 ± 2.3
0.323
Hot flashes
−2.2 ± 2.6
−0.2 ± 2.7
0.116
−1.4 ± 2.2
−3.9 ± 1.9
0.032
Sweating
−2.4 ± 3.4
−0.5 ± 3.2
0.129
−0.7 ± 1.3
−2.8 ± 2.0
0.039
Difficulty in sleeping
−1.9 ± 2.2
−0.9 ± 1.8
0.363
−1.9 ± 2.0
−3.1 ± 2.4
0.416
Waking up at night
−0.5 ± 3.1
−1.2 ± 2.5
0.894
−1.9 ± 2.3
−2.6 ± 2.5
0.533
Data are the mean changes from baseline of climacteric symptoms at week 12 in the placebo nonresponder group.
