Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia

Figure 1

The effect of NCNL on the mammary pathology (a), mammary gland index (b), and protein expression (c, d) in rats with hypogalactia. Tissue staining with H&E (a). All tissues were observed using a light microscope; representative images are shown (×400). Mammary gland to body weight ratio (b). Expression of prolactin and albumin was determined by western blotting (c-d). Relative expression of prolactin and albumin was calculated using β-actin for normalization. Normal: normal group. Control: bromocriptine-induced hypogalactia control group. CNL: traditional Cui Nai Ling aqueous extract 1000 mg/kg administered group. NCNLL: new Cui Nai Ling aqueous extract 500 mg/kg administered group. NCNLH: new Cui Nai Ling aqueous extract 1000 mg/kg administered group. The data are expressed as the mean ± standard deviation (n = 7). , , and versus the normal group; , , and versus the control group.

(a)

(b)

(c)

(d)