Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia

Figure 2

Network construction, pathway, and functional enrichment analysis of the effect of NCNL on hypogalactia. Potential active ingredient-target-disease network. (a) Different color symbols as mentioned here: disease (yellow), NCNL (red), targets (green), and compounds (purple). PPI network. (b) Node information as mentioned here: query proteins and first shell of interactors (colored nodes), the second shell of interactors (white nodes), proteins of unknown 3D structure (empty nodes), and some 3D structures being known or predicted (filled nodes), curated databases (), experimentally determined (), gene neighborhood (), gene fusions (), gene co-occurrence (), text mining (), coexpression (), and protein homology (). (c) GO function analysis. (d) KEGG pathway enrichment analysis: the gradual change in color represented the change in probability. (e) PI3K-AKT signaling pathway.

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