Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia
Table 1
Effect of NCNL on the physiological signs of rats with postpartum hypogalactia.
Group
D0
D1
D2
D3
D4
D5
D6
D7
Rat weight (g)
Normal
316.00 ± 26.67
318.25 ± 27.13
314.00 ± 26.18
319.00 ± 25.43
320.00 ± 28.22
312.75 ± 25.76
320.50 ± 27.89
323.50 ± 28.34
Control
310.80 ± 21.33
311.80 ± 23.61
293.00 ± 25.88
317.00 ± 24.89
311.60 ± 24.95
314.20 ± 23.64
315.60 ± 22.90
317.20 ± 21.35
CNL
307.00 ± 14.76
315.00 ± 11.45
287.57 ± 9.39
305.14 ± 8.59
302.57 ± 8.66
304.85 ± 8.49
305.00 ± 8.16
305.43 ± 10.98
NCNLL
309.00 ± 11.36
319.00 ± 16.70
288.20 ± 16.03
310.60 ± 11.51
309.60 ± 14.58
308.40 ± 16.64
310.00 ± 18.70
309.40 ± 17.49
NCNLH
314.66 ± 25.75
319.67 ± 37.75
299.67 ± 29.89
318.67 ± 28.50
316.16 ± 27.72
318.16 ± 29.05
316.67 ± 28.93
313.50 ± 25.19
Pups’ weight (g)
Normal
112.74 ± 22.35
132.62 ± 22.11
152.82 ± 22.64
173.66 ± 22.38
194.96 ± 21.79
216.40 ± 21.90
236.66 ± 21.98
259.72 ± 21.36
Control
109.65 ± 6.20
115.88 ± 5.44
120.53 ± 4.89
128.00 ± 6.59
131.83 ± 7.56
133.58 ± 6.99
130.48 ± 6.42
129.30 ± 5.81
CNL
103.07 ± 5.62
110.46 ± 5.16
117.77 ± 5.35
125.13 ± 8.21
133.39 ± 10.78
140.14 ± 13.77
145.83 ± 18.05
153.41 ± 22.62
NCNLL
109.06 ± 6.13
119.96 ± 9.55
128.04 ± 10.74
140.70 ± 13.59
152.02 ± 16.19
163.52 ± 18.83
172.98 ± 20.58
188.10 ± 23.23
NCNLH
107.08 ± 7.42
112.65 ± 10.71
123.87 ± 10.30
133.50 ± 13.38
142.95 ± 16.46
151.45 ± 19.76
157.52 ± 23.86
171.05 ± 26.89
Food intake (g)
Normal
35.23 ± 2.91
32.66 ± 2.31
39.05 ± 5.82
42.29 ± 4.28
45.12 ± 3.01
46.56 ± 6.09
48.16 ± 6.45
49.88 ± 2.17
Control
26.62 ± 8.55
29.15 ± 7.03
29.35 ± 4.69
38.33 ± 4.02
32.14 ± 5.33
28.44 ± 4.47
27.99 ± 1.57
27.59 ± 4.43
CNL
26.92 ± 2.43
31.88 ± 4.40
23.21 ± 3.02
31.11 ± 6.77
31.22 ± 3.90
31.29 ± 5.62
30.72 ± 6.06
30.52 ± 5.69
NCNLL
30.19 ± 7.77
36.95 ± 4.82
30.75 ± 7.71
37.69 ± 4.76
37.26 ± 4.54
40.94 ± 6.43
37.39 ± 5.46
37.30 ± 4.20
NCNLH
30.04 ± 11.57
32.99 ± 6.93
26.59 ± 4.31
36.68 ± 3.93
35.56 ± 6.09
37.18 ± 5.68
34.18 ± 3.85
35.90 ± 4.05
Water intake (mL)
Normal
49.38 ± 4.80
50.37 ± 10.54
56.13 ± 7.63
67.90 ± 16.33
62.46 ± 12.63
59.60 ± 15.58
60.79 ± 14.84
67.81 ± 13.00
Control
57.74 ± 13.95
65.16 ± 9.29
24.74 ± 6.32
91.20 ± 16.54
67.40 ± 8.39
60.24 ± 19.39
56.35 ± 14.54
54.01 ± 11.64
CNL
53.97 ± 7.92
61.25 ± 8.94
16.93 ± 3.85
81.69 ± 23.89
59.92 ± 10.93
58.73 ± 12.35
56.00 ± 11.51
60.93 ± 13.71
NCNLL
59.98 ± 19.39
54.60 ± 9.72
24.65 ± 7.63
80.79 ± 31.63
59.83 ± 14.79
58.95 ± 16.74
62.46 ± 14.68
63.37 ± 13.93
NCNLH
66.53 ± 27.68
71.27 ± 23.85
26.12 ± 7.96
96.75 ± 25.53
71.22 ± 28.43
71.76 ± 20.98
79.22 ± 32.22
76.98 ± 27.13
The data are expressed as the mean ± SD (n = 7); versus the normal group; versus the control group. Normal: normal group. Control: bromocriptine-induced hypogalactia control group. CNL: traditional Cui Nai Ling aqueous extract 1000 mg/kg administered group. NCNLL: new Cui Nai Ling aqueous extract 500 mg/kg administered group. NCNLH: new Cui Nai Ling aqueous extract 1000 mg/kg administered group.
