Alismatis Rhizoma Triterpenes Alleviate High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle of Mice

Figure 3

ART treatment improves IR by regulating glucose tolerance and insulin sensitivity in IR mice. (a) Body weight of four groups of mice, namely, the CHOW group (normal diet, n = 10), HFD group (high-fat diet, n = 10), HFD + ART group (high-fat diet with ART treatment, 200 mg/kg, n = 10), and HFD + POS group (high-fat diet with positive drug metformin treatment, 200 mg/kg, n = 10), in 14 weeks were recorded. (b–f) Result of FBG (b), FIINS (c), HOMA-IR (d), HbA1C (e), and FFA (f), level in the blood of each group. (g and h) The glucose level (g) of each group in the IPGTT assay was determined, and the AUC (h) was calculated. Glucose level (i) of each group in the IPITT assay was determined, and the AUC (j) was determined as well. (k and l) Result of tumor TNF- (k) and MCP-1 (l) expression of each group.  < 0.01 vs. CHOW group,  < 0.01 vs. HFD group.

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