The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo

Figure 1

PVE inhibits the proliferation of TC cells. (a) After cultured at complete culture medium containing PVE for 72 (h) the growth of TPC-1 and SW579 cells was significantly inhibited compared to Nthy-ori 3–1 normal thyroid cell line, suggesting that they were more sensitive to PVE treatment than other TC cell lines. ((b), (c)) PVE inhibited the increase of cell number in a dose-dependent manner. ((d), (e)) Colony numbers decreased with increasing PVE concentration. ((f–h)) Cell cycle distribution analysis showed that PVE induced the arrest of both TPC-1 and SW579 cells in the S phase and increased the proportion of SW579 cells in the G0/G1 phase. However, the decrease in TPC-1 cells in the G0/G1 phase after PVE treatment was not statistically significant. All data are presented as the mean ± SD. One-way ANOVA was performed to identify statistically significant differences (, , and ).

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