The Antitumour Effect of <i>Prunella vulgaris</i> Extract on Thyroid Cancer Cells In Vitro and In Vivo

<div>PVE suppresses TC progression via repressing the transcription and translation of MKI67, PCNA, and CDH1. (a) qRT-PCR analysis of xenograft tissue showed that MKI67, PCNA, and CDH1 were significantly downregulated at the transcriptional level after PVE treatment, while CTNNB1 was significantly upregulated. ((b), (c)) Western blot analysis of MKI67, PCNA, CTNNB1, and CDH1 expression in xenograft tissue with and without PVE treatment. (d) The interaction among MKI67, PCNA, CDH1 and relative proteins. ((e), (f)) KEGG pathway and GO analysis for proteins interacting with MKI67, PCNA, CDH1. All data are presented as the mean ± SD. 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Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: The Antitumour Effect of <i>Prunella vulgaris</i> Extract on Thyroid Cancer Cells In Vitro and In Vivo 

Evidence-Based Complementary and Alternative Medicine

The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo

Figure 4