Protective Effect of Capparis spinosa Extract against Potassium Bromate Induced Oxidative Stress and Genotoxicity in Mice

Table 2

Frequency of micronucleus induced by KBrO₃ alone or in combination with different doses of C. spinosa extracts in the peripheral blood of mice exposed for 24, 48, and 72 hours.

Treatment time (h)	Treatment (mg/kg bw)	MNPCE	PCE/NCE
		Mean ± SD	Mean ± SD
24	Control	3.36 ± 0.19	1.12 ± 0.25
	150 PB	16. 50 ± 3.22	0.89 ± 0.25
	150 PB + 50 CS	5.25 ± 1.35	1.08 ± 0.45
	150 PB + 100 CS	5.75 ± 1.88	0.99 ± 0.34
	150 PB + 150 CS	9. 70 ± 2.42	0.98 ± 0.35
48	Control	3.22 ± 0.31	1.05 ± 0.21
	150 PB	17. 50 ± 3.22	0.85 ± 0.35
	150 PB + 50 CS	6.21 ± 1.44	1.04 ± 0.34
	150 PB + 100 CS	5.21 ± 1.48	0.97 ± 0.33
	150 PB + 150 CS	10.45 ± 2.05	0.95 ± 0.35
72	Control	3.74 ± 0.23	1.23 ± 0.19
	150 PB	21.50 ± 3.05	0.84 ± 0.31
	150 PB + 50 CS	13.60 ± 1.18	1.05 ± 0.39
	PB + 100 CS	12.58 ± 2.09	0.99 ± 0.42
	150 PB + 150 CS	10.25 ± 2.35	0.89 ± 0.51

Student’s t-test  < 0.05. PB: potassium bromate; CS: C. spinosa extracts. 2000 PCE were analysed for each animal (n = 5).