Standardized Extract (HemoHIM) Protects against Scopolamine-Induced Amnesia in a Murine Model
The effects of HemoHIM on scopolamine-induced memory impairment in the Y-maze test. Spontaneous alternation (%) was calculated as follows. % = (Number of alternations/Total arm entries − 2) × 100. Spontaneous alternation (a) and numbers of total arm entry (b) were measured for Y-maze test. Ninety minutes before Y-maze, mice were treated with HemoHIM (250 and 500 mg/kg, p.o.) or donepezil (1 mg/kg, p.o.) as a positive control. Memory impairment was induced by scopolamine treatment (1 mg/kg, i.p.). Thirteen different animals were used per group. The data are expressed as the mean ± S.E.M. Significant difference from control group ( < 0.001) and from scopolamine-treated group ( < 0.001, < 0.01).
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