Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination

Figure 1

(a, b) Temporal courses of number of flinches induced by the injection of 50 μL 1% formalin into the dorsal surface of the right paw of the rats. The flinches induced by formalin were counted every 5 minutes for 1 minute to complete 60 minutes of evaluation in the presence of R. officinalis (a), S. aromaticum (b), or vehicle (Veh). All treatments were injected into the dorsal surface of the right paw of the rats 15 minutes before formalin. Each point represents the average of 6 animals tested ± SEM. (c) AUCs obtained from temporal courses of number of flinches in the presence of R. officinalis, S. aromaticum, or Veh. Each bar represents the mean AUC of 6 animals ± SEM. Significant difference from vehicle group () as determined by a one-way ANOVA followed by Dunnett’s test.

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