Procyanidin B2 Alleviates Palmitic Acid-Induced Injury in HepG2 Cells via Endoplasmic Reticulum Stress Pathway

Figure 6

PCB2 alleviates endoplasmic reticulum stress in PA-induced HepG2 cells. Cells were exposed to PA (125 μM) and treated by PCB2 (2.5, 5, and 10 μM) for 24 h. The protein levels were examined by Western blotting. (a) The protein levels of GRP78 and GRP94. (b) The protein levels of p-PERK and PERK. (c) The protein levels of p-eIF2α and eIF2α. (d) The protein levels of p-IRE1, IRE1α, and CHOP. (e) Cell viability of model, PCB2 (10 μM), and ERS pathway inhibitor/agonist-related groups. (f) HepG2 cells were treated as in (e), and the relative protein levels of GRP78 and CHOP were measured by Western blot. ^### < 0.001 vs control,  < 0.01 and  < 0.001 vs model group.

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