Microencapsulated Recombinant Human Epidermal Growth Factor Ameliorates Osteoarthritis in a Murine Model

Figure 3

Effects of HA, rhEGF, and HA/Me-rhEGF on MIA-induced OA rats. (a) Sizes of knee joints measured by a knee diameter, and (b) joint lesions, including destructive tissue structure, chondrocyte and cartilage loss, and total Mankin grades, were examined and are presented as mean ± SEM. (c) Representative images of histological alterations in the knee joints as indicated by H&E staining and safranin O/fast green staining. (d) COMP and CTX-II in serum were measured by ELISA as cartilaginous degradation indicators (mean ± SEM from three independent experiments).

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