GuanXinNing Tablet Attenuates Alzheimer’s Disease via Improving Gut Microbiota, Host Metabolites, and Neuronal Apoptosis in Rabbits

Figure 4

GXN reduced blood lipid levels, improved memory and behaviors, and alleviated Aβ deposition in the brains of AD rabbits. (a) The effects of GXN on body weight and TC, TG, HDL-C, and LDL-C levels in AD rabbits. (b) Representative traces of the path traveled by each group in the memory and behavior test. (c) Quantitative analysis of the distance traveled and time to reach a fixed point of each group. (d, f) Representative images of Aβ and thioflavin-T staining in each group. Scale bar = 50 mm. White or black boxes indicate the region shown at higher magnification below each panel. (e, g) Quantitative analysis of Aβ levels and plaque-covered area in each group. n = 6.

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