GuanXinNing Tablet Attenuates Alzheimer’s Disease via Improving Gut Microbiota, Host Metabolites, and Neuronal Apoptosis in Rabbits

Figure 8

GXN altered serum metabolite levels in AD rabbits: (a) PLS-DA score plot for each group, (b) permutation test of the PLS-DA model, (c) OPLS-DA score plot of the AD group versus the GXN group, (d) relative serum contents of different metabolites in rabbits from each group, and (e) schematic representation of pathways identified by MetaboAnalyst 5.0. The ordinate indicates the significance level of the metabolic pathway, and the abscissa indicates the importance of the metabolic pathway. (1) D-glutamine and D-glutamate metabolism; 2. glycine, serine, and threonine metabolism; 3. glycerolipid metabolism; 4. alanine, aspartate, and glutamate metabolism; 5. glyoxylate and dicarboxylate metabolism; 6. arginine biosynthesis; and 7. glutathione metabolism. n = 6. Red and blue indicate positive correlations and negative correlations, respectively.

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