|
| Compound (rutin with other agents) | Mechanism | Cancer cell line | Reference |
|
| Quercetin, myricetin | Protection of cancer cells against hydrogen peroxide | Caco-2 and HepG2 | [35, 36] |
| Quercetin | Decrease the activity of oxygen radical | Human hepatocellular carcinoma (HepG2) | [37–39] |
| AgNPs and natural bioactive compounds | Represent novel therapeutics fighting and synergistic, antimicrobial effects | Epithelioma papulosum cyprini (EPC) cell lines | [40] |
| Dietary polyphenols | Inducing cell cycle arrest or apoptosis, metastasis, and angiogenesis | Colorectal cancer cell lines | [41] |
| Fucoidan | Nuclear fragmentation, and mitochondrial potential loss, ROS generation | HaCaT (immortal noncancerous keratinocyte), HeLa (epithelial adenocarcinoma cells of the cervix) | [27] |
| Liquid crystalline nanoparticles | Inhibited the genes, namely, Nox2B and Nox4, which caused oxidative stress, upregulation in the expression of the antioxidant genes Gclc and Nqo-1 | Human bronchial epithelial cells (BEAS-2B) | [36, 42] |
| Quercetin | Reduce the enzymes precarcinogenic compounds such as CYP1A | Intestinal HCT‐8 Cells | [38, 42] |
| Diosmin and Tangeretin | Antimetastatic effects | Melanoma B16F10 cancer cells | [43] |
| Zinc(II) flavonoid-metal complex | Modulated expression of genes related to angiogenesis, cell cycle progression | Leukaemia (KG1, K562, and Jurkat), melanoma (B16F10 and SK-Mel-28), and multiple myeloma (RPMI8226) cell lines | [44] |
| Ionic liquids nanoparticles | Caused a significant increase in the sub-G1 population, a significant decrease in cell viability | Human renal cancer cell line (786-O) | [45] |
| Silibinin | Anticancer, apoptosis effects regulating the expressions of genes apoptosis, inflammation, and MAPK pathway proteins | Human colon cancer cell line | [46] |
| Poly (D, L-lactic-co-glycolic acid) (PLGA) nanospheres, Benzamide | Cell cycle disruption and apoptotic induction | MDA-MB-231 | [47] |
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