An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Figure 3

GO analysis of key targets. There are four circles in the figure. From outside to inside, the first circle is the classification of enrichment. Different colors represent different classifications. The second circle shows the number of background genes and value. The more genes, the longer the bars; the smaller the value, the redder the color. The third circle is the total number of prospective genes. The forth circle represents the RichFactor, which indicates ratio of genes in the current study versus the total genes in the term. GO:0005634, nucleus; GO:0005813, centrosome; GO:0005886, plasma membrane; GO:0009986, cell surface; GO:0005654, nucleoplasm; GO:0016020, membrane; GO:0004879, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding; GO:0004714, transmembrane receptor protein tyrosine kinase activity; GO:0005524, ATP binding; GO:0004713, protein tyrosine kinase activity; GO:0004672, protein kinase activity; GO:0004693, cyclin-dependent protein serine/threonine kinase activity; GO:0005515, protein binding; GO:0048146, positive regulation of fibroblast proliferation; GO:0001525, angiogenesis; GO:0006977, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0048010, vascular endothelial growth factor receptor signaling pathway; GO:0007169, transmembrane receptor protein tyrosine kinase signaling pathway; GO:0006979, response to oxidative stress; GO:0034612, response to the tumor necrosis factor.