An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Table 1

Active compounds and targets of RRER.

No.	Active compounds	OB (%)	DL	Targets
1	Eupatin	50.8	0.41	XDH, CYP1B1, AKR1B1, PLG, OPRD1, MAPT, KDM4E, GPR35, AVPR2, TOP2A, CYP19A1, DRD4, GLO1, MPO, PIK3R1, DAPK1, PYGL, CA3, ABCC1, PLK1, CA6, PKN1, CSNK2A1, NEK2, CAMK2B, ALK, AKT1, NEK6, PLA2G1B, APEX1, NUAK1, AKR1C2, AKR1C1, AKR1C3, AKR1C4, AKR1A1, CA2, CA12, ALOX5, GSK3B, HSD17B2, ABCG2, CCNB1, CCNB3, CCNB2, CDK1, CDK6, ARG1, ADORA3, BACE1, APP, CA7, ADORA1, MMP3, MMP2, NOX4, EGFR, PIK3CG, MAOA, TYR, AHR, ESRRA, MET, FLT3, ADORA2A, KDR, IGF1R, INSR, SRC, PTK2, CA1, CA13, MMP13, CA4, MMP9, ALOX12, AURKB, ST6GAL1, CDK2, HSD17B1, CA9, PTPRS, MPG, SLC22A12, AXL, ABCB1, ODC1, PFKFB3, F2, CA14, CA5A, CD38, AKR1B10, TNKS2, TNKS, TOP1, MYLK, ALOX15, PIM1, CXCR1, PLA2G2A, ACHE, SYK
2	Mutatochrome	48.64	0.61	ALOX5
3	Physciondiglucoside	41.65	0.63	ESR1, TNNC1, TNNT2, TNNI3, EPHX2, SLC5A1, CA14, LGALS3, LGALS9, SLC5A2, CHIA, SLC29A1, ADORA2A, CYP19A1, ADORA3, MME, ECE1, LGALS4, LGALS8, SLC5A4, ACE, HRAS, ADORA2B, TYR
4	Procyanidin B-5,3′-O-gallate	31.99	0.32	MMP2, MAPT, DYRK1A, KCNH2, MAPK14, TERT, PGD, ST3GAL3, FUT7, BCL2, FUT4, STAT1, SQLE, BACE1, APP, MMP14, MET, ABCB1, DNMT1, MMP9, GABRA1, GABRB2, GABRG2, MMP12, PGF, VEGFA, HIF1A, CA2, CA1, CA9, ABCC1, ABCG2, PTGS1, CYP19A1, KLK1, KLK2, POLB, PLA2G2A, PLA2G5, PLA2G10, CYP1B1
5	Rhein	47.07	0.28	FTO, CYP19A1, ELANE, FNTA, FNTB, PTP4A3, CSNK2A1, ESR2, PIM1, CASP3, LDHA, LDHB, ERN1, ESR1, CDC25 B, BCL2, MCL1, AMPD3, ECE1, LIMK1, F2, SLC13A5, LCK, IGFBP3, GRK6, EGLN1, MME, CDK2, HNF4A, MAPK8, OGA, GPR35, ADA, ACLY, CASP6, CASP7, CASP8, CASP1, CASP2, NOX4, CAMKK2, ERBB2, SLC6A3, EGFR
6	Sennoside E_qt	50.69	0.61	FTO, ELANE, AKR1B1, CYP19A1, PIM1, CA2, CA1, TOP1, SELL, SELE, SELP, PTP4A3, CSNK2A1, BMP1, AMPD3, HSP90AB1, ACE, MME, PDE5A, MMP9, MMP1, MMP2, MMP8, ESR1, ESR2, HSP90AA1, KDM4C, PTGDR2, ECE1, PTGER1, PTGER2, IKBKB, PTGER3, AMPD2, PIK3CA, FNTA, FNTB, KDM3A, HCAR2, ITGB1, AGTR1, LTA4H, ITGB7, ITGA4, HTR2B, RAF1, SLC5A2, BRAF, EGLN1, TTL, MAPK8, PTGFR, MMP10, MMP12, TKT, FOLH1, RXRA, HNF4A, FLT1, KDM4A, MMP14, CXCR2, PYGL, PNP, CASP3, PTGER4, IGFBP3, MKNK2, EGFR, ITGAV, ITGB3, ADAMTS4, CASP6, CASP7, CASP8, CASP1, F7, CREBBP, FYN, OPRM1, IGFBP5, TTR, CHEK1, WEE1, KIT, CTSD, DYRK2, GSK3B, DPP4, GSK3A, AKR1B10, PDE4B, AMPD1, PDE4D, ROCK1, SCN9A, PTGIR, P2RX3, KCNH2, ACLY, CDK5, BCL2L2
7	Torachrysone-8-O-beta-D-(6′-oxayl)-glucoside	43.02	0.74	EPHX2, TYR, SRD5A1, TDP1, SLC5A2, PTPN1, SLC5A1, SLC5A4, CA14, ADORA2A, SLC29A1, HK2, HK1, AKR1B1, PYGL, ADORA3, EIF4H, PABPC1, PIM1, FUCA1, ADORA2B, NR4A1, IGFBP3
8	Toralactone	46.46	0.24	PTGS2, GUSB, SERPINE1, FADS1, CA1, CA12, CA9, IMPDH2, RET, QPCT, TYMS, PLAU, PDE5A, PTK2B, ABCB1, MTOR, PIK3CD, PIK3CB, HCK, PIK3CA, DYRK1B, JAK3, PLA2G7, ILK, TUBB1, TUBB3, RPS6KA3, AKR1B1, EGLN1, FLT1, DHFR, EPHB2, MDM2, MAOA, RAF1, FGFR1, CXCR2, MAOB, LNPEP
9	Emodin-1-O-beta-D-glucopyranoside	44.81	0.8	ESR1, TNNC1, TNNT2, TNNI3, EPHX2, SLC5A4, SLC5A2, SLC5A1, CA7, CA4, ELANE, SLC29A1, SLC28A3, ACHE, NQO2, PTPN1
10	Sennoside D_qt	61.06	0.61	TNNC1, TNNT2, TNNI3, ESR1
11	Daucosterol_qt	35.89	0.7	IL2, STAT3, APH1B, PSEN1, APH1A, NCSTN, PSENEN, PSEN2, PTAFR, MET, S1PR3, S1PR1, FLT1, RBP4, PPM1B, PPP1CC, PPP2CA, PPP2R5A, HSD11B2, S1PR5, S1PR4
12	Palmidin A	32.45	0.65	PTP4A3, PIM1, CSNK2A1, FTO, ESR1, ESR2, MAP3K14, MAP3K7, HSP90AA1, HDAC6, HDAC2, HDAC1, HMGCR, CXCR2, CXCR1, RXRA, TOP1, PARP1, PDK1, HNF4A, PDE5A, KIT, FLT3, KDR, MAP2K2, MAPKAPK5, TYK2, MAPK1, ALK, MMP9, MMP1, MMP2, MMP8, ACVRL1, ADORA3, MMP13, MMP3, ADAM17, CTSV, PLK4, CDK5, MKNK2, AXL, SORD, CDK2, CCND1, CDK4, SYK, GSK3B, GSK3A, MCL1, MMP7, MMP12, ELANE, ADCY1, MAP2K7, MAP2K1, RELA, FLT1, PDGFRB, FLT4, PDGFRA, MAPK3, PLG, APH1B, PSEN1, APH1A, NCSTN, PSENEN, PSEN2, PLAU, IRAK4, PRKCB, CCNB2, CCNB1, CDK1, CCNB3, CCNA2, CCNA1, RPS6KA3, AKR1B1, PDE4B, PIK3CD, PIK3CB, PIK3CG, MAP3K1, PIK3CA, IMPDH1, AURKA, P2RX7, CA2, OPRK1, CA1, CA12, CA9, JUN, P2RX3, PRKCD, NTRK1, GYS1, BACE1, LCK, CA4, WEE1, CCNE1, BCHE, CCNH, CDK7, CCNT1, CDK9, DYRK1A
13	Beta-sitosterol	36.91	0.75	AR, HMGCR, CYP51A1, NPC1L1, NR1H3, CYP19A1, CYP17A1, RORC, ESR1, ESR2, SREBF2, SHBG, SLC6A2, CYP2C19, RORA, PTPN1, BCHE, SERPINA6, SERPINA6, SLC6A4, CHRM2, VDR, ACHE, G6PD, NR1H2, GLRA1, CES2, PTGER1, PTGER2, HSD11B1, PTGES, CDC25 A, PPARA, PPARD, DHCR7, SQLE, PTPN6, NR1I3, FDFT1, SIGMAR1, NOS2, NR3C1, PPARG, CDC25 B, UGT2B7, HSD11B2, POLB
14	Aloe-emodin	83.38	0.24	PTGS1, PTGS2, HSP90AB1, HSP90AA1, PIK3CG, NCOA2, PKIA, AKR1B1, IGHG1, CDKN1A, EIF6, BAX, TNF, CASP3, TP53, FASN, PRKCA, PRKCE, CDK1, PCNA, MYC, IL1B, PRKCD, CCNB1
15	Gallic acid-3-O-(6′-O-galloyl)-glucoside	30.25	0.67	TDP1, SERPINE1, PTPN2, BACE1, ADORA1, AKR1B1, ASNS, AMY1A
16	(-)-Catechin	49.68	0.24	PTGS1, ESR1, PTGS2, HSP90AB1, HSP90AA1, DPEP1, NCOA2, FASN, PPARG, KLF7