An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of Radix Rhei Et Rhizome: A Network Pharmacology Study

Table 3

Network topology analysis of key targets (top 20 of degree).

No.	Targets	Degree	Average shortest path length	Closeness centrality	Neighborhood connectivity	Radiality
1	ESR1	8	2.57746479	0.38797814	7.125	0.7370892
2	ESR2	4	2.71830986	0.36787565	12.5	0.71361502
3	HSP90AA1	4	2.74647887	0.36410256	12.75	0.70892019
4	FLT1	4	2.63380282	0.37967914	12.75	0.72769953
5	CCNB1	3	2.6056338	0.38378378	16	0.73239437
6	CDK1	3	2.6056338	0.38378378	16	0.73239437
7	EGFR	3	3.02816901	0.33023256	10.33333333	0.66197183
8	MET	3	3.45070423	0.28979592	7	0.5915493
9	CDK2	3	2.71830986	0.36787565	15.33333333	0.71361502
10	PIK3CA	3	2.85915493	0.34975369	15.66666667	0.69014085
11	KDR	2	2.8028169	0.35678392	19.5	0.69953052
12	BCL2	2	3.81690141	0.26199262	6	0.53051643
13	MCL1	2	2.94366197	0.33971292	17	0.67605634
14	RAF1	2	3.42253521	0.29218107	10	0.59624413
15	RXRA	2	3	0.33333333	19.5	0.66666667
16	KIT	2	3	0.33333333	19.5	0.66666667
17	PIK3CB	2	3	0.33333333	17.5	0.66666667
18	PPARG	2	4.21126761	0.23745819	3.5	0.46478873
19	PIK3R1	1	3.84507042	0.26007326	12	0.5258216
20	PLK1	1	3.84507042	0.26007326	12	0.5258216