A Pilot Study of Whether the Cold-Heat Syndrome Type is Associated with Treatment Response and Immune Status in Patients with Non-Small Cell Lung Cancer
Table 3
Clinical characteristics of 20 patients classified by the cluster analysis.
Group A (n = 15)
Group B (n = 5)
value
Age (year)
60.5 ± 11.1
63.6 ± 9.2
0.577
Sex
—
—
0.011
Female
0 (0.0%)
3 (60.0%)
Male
15 (100.0%)
2 (40.0%)
Cold syndrome (ZHENG) symptomsa
I have an aversion to cold
3.3 ± 1.2
5.0 ± 0.0
<0.001
I need to stay very warm
3.5 ± 1.0
5.0 ± 0.0
<0.001
I have experienced coldness in the abdomen
2.5 ± 1.4
4.0 ± 1.4
0.059
I feel coldness in my hands and feet
2.8 ± 1.4
3.0 ± 1.4
0.788
I have had painful cold sensations in my body
2.7 ± 1.3
4.2 ± 1.8
0.056
My face looks pale
1.5 ± 0.6
3.6 ± 1.7
0.045
I cannot drink cold water
2.9 ± 1.4
5.0 ± 0.0
<0.001
I urinate colorless urine
3.2 ± 1.0
3.2 ± 1.6
0.999
Heat syndrome (ZHENG) symptomsa
I like a cool feeling
3.5 ± 1.0
1.4 ± 0.5
<0.001
I do not like hot or warm atmosphere
2.4 ± 1.0
1.4 ± 0.5
0.047
I have hot or fever sensation in my body
2.9 ± 1.3
1.8 ± 1.8
0.147
I have burning sensation in my body
1.8 ± 1.1
2.2 ± 1.6
0.537
My face looks red or eyes are blood shot
1.8 ± 1.0
1.6 ± 0.9
0.700
I like to drink cold water
3.6 ± 1.1
1.2 ± 0.4
<0.001
My breath has been hot
2.1 ± 1.0
1.4 ± 0.9
0.160
Non-cold/cold type
—
—
0.020
Non-cold type
11 (73.3%)
0 (0.0%)
Cold type
4 (26.7%)
5 (100.0%)
PD-L1b
—
—
0.051
Negative
2 (14.3%)
3 (60.0%)
>0%, ≤50%
4 (28.6%)
2 (40.0%)
>50%
8 (57.1%)
0 (0.0%)
a Each item is measured as a 5-point Likert score ranging (1 to 5).
