Based on Network Pharmacology and Molecular Docking to Explore the Underlying Mechanism of Huangqi Gegen Decoction for Treating Diabetic Nephropathy

Table 3

Information about core targets and topology attributes.

Target name	Protein name	Degree	Closeness centrality	Betweenness centrality
VEGFA	Vascular endothelial growth factor A	84	0.875	0.03102384
IL6	Interleukin-6	84	0.875	0.04051797
TNF	Tumor necrosis factor	82	0.85964912	0.03718661
AKT1	RAC-alpha serine/threonine-protein kinase	82	0.85964912	0.04888032
TP53	Cellular tumor antigen p53	77	0.82352941	0.02116743
CASP3	Caspase-3	73	0.79674797	0.01770724
SRC	Proto-oncogene tyrosine-protein kinase Src	71	0.784	0.01916334
EGF	Pro-epidermal growth factor	70	0.765625	0.0160755
PTGS2	Alcohol dehydrogenase 1 B	69	0.765625	0.01023162
MAPK1	Mitogen-activated protein kinase 1	69	0.77165354	0.01315146
JUN	Transcription factor AP-1	67	0.75968992	0.00962486
CXCL8	Interleukin-8	66	0.7480916	0.01010843
MAPK8	Mitogen-activated protein kinase 8	66	0.75384615	0.00948131
MMP9	Matrix metalloproteinase-9	66	0.75384615	0.00961004
IL10	Interleukin-10	63	0.73684211	0.00935327
IL1 B	Interleukin-1 beta	62	0.72592593	0.01073204
CCL2	C-X-C motif chemokine 2	61	0.72592593	0.00853585
NOS3	Nitric-oxide synthase, endothelial	60	0.72058824	0.01623335
PTEN	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	60	0.72058824	0.0101365
MTOR	Serine/threonine-protein kinase mTOR	57	0.70503597	0.00941808
PPARG	Peroxisome proliferator-activated receptor gamma	56	0.7	0.00919915
ESR1	Estrogen receptor	56	0.7	0.01962422
FOS	Proto-oncogene c-Fos	54	0.69014085	0.01005477
SIRT1	Signal transducer and activator of transcription 1-alpha/beta	54	0.69014085	0.01725096
HRAS	GTPase HRas	54	0.69014085	0.00737461
CRP	C-reactive protein	49	0.66216216	0.00821785
HIF1A	Hypoxia-inducible factor 1-alpha	48	0.65771812	0.02349361