Based on Network Pharmacology and Molecular Docking to Explore the Underlying Mechanism of Huangqi Gegen Decoction for Treating Diabetic Nephropathy

Table 4

Enrichment results of target pathway.

Id	KEGG pathway	value	Targets	Count
Hsa04668	TNF signaling pathway	2.84E − 14	IL6, Jun, MAPK8, IL1 B, CASP3, MAPK1, CCL2, AKT1, FOS, PTGS2, TNF, MMP9	12
Hsa04620	Toll-like receptor signaling pathway	2.12E − 09	IL6, Jun, MAPK8, CXCL8, IL1 B, MAPK1, AKT1, FOS, TNF	9
Hsa04010	MAPK signaling pathway	7.62E − 09	Jun, MAPK8, EGF, IL1B, CASP3, MAPK1, AKT1, FOS, HRAS, TNF, TP53	11
Hsa04068	FoxO signaling pathway	1.38E − 08	IL10, IL6, MAPK8, EGF, PTEN, MAPK1, AKT1, HRAS, SIRT1	9
Hsa04066	HIF-1 signaling pathway	3.24E − 08	IL6, EGF, NOS3, MAPK1, AKT1, HIF1A, MTOR, VEGFA	8
Hsa04621	NOD-like receptor signaling pathway	3.48E − 08	IL6, MAPK8, CXCL8, IL1B, MAPK1, CCL2, TNF	7
Hsa04370	VEGF signaling pathway	5.88E − 08	Src, NOS3, MAPK1, AKT1, PTGS2, HRAS, VEGFA	7
Hsa04151	PI3K-Akt signaling pathway	1.81E − 06	IL6, EGF, NOS3, PTEN, MAPK1, AKT1, HRAS, TP53, MTOR, VEGFA	10
Hsa04931	Insulin resistance	1.81E − 06	IL6, MAPK8, NOS3, PTEN, AKT1, TNF, MTOR	7
Hsa04150	mTOR signaling pathway	5.04E − 05	Pten, MAPK1, AKT1, TNF, MTOR	5