Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking

Table 1

Ingredients in Scutellariae radix-Coptidis rhizoma drug pair.

Drug source	Molecule ID	Molecule name	OB (%)	DL
Scutellariae radix	MOL001689	Acacetin	34.97	0.24
	MOL000173	Wogonin	30.68	0.23
	MOL000228	(2R)-7-Hydroxy-5-methoxy-2-phenylchroman-4-one	55.23	0.2
	MOL002714	Baicalein	33.52	0.21
	MOL002909	5,7,2,5-Tetrahydroxy-8,6-dimethoxyflavone	33.82	0.45
	MOL002910	Carthamidin	41.15	0.24
	MOL002913	Dihydrobaicalin_qt	40.04	0.21
	MOL002914	Eriodyctiol (flavanone)	41.35	0.24
	MOL002915	Salvigenin	49.07	0.33
	MOL002917	5,2′,6′-Trihydroxy-7,8-dimethoxyflavone	45.05	0.33
	MOL002925	5,7,2′,6′-Tetrahydroxyflavone	37.01	0.24
	MOL002927	Skullcapflavone II	69.51	0.44
	MOL002928	Oroxylin A	41.37	0.23
	MOL002932	Panicolin	76.26	0.29
	MOL002933	5,7,4′-Trihydroxy-8-methoxyflavone	36.56	0.27
	MOL002934	Neobaicalein	104.34	0.44
	MOL002937	Dihydrooroxylin	66.06	0.23
	MOL000358	Beta-sitosterol	36.91	0.75
	MOL000359	Sitosterol	36.91	0.75
	MOL000525	Norwogonin	39.4	0.21
	MOL000552	5,2′-Dihydroxy-6,7,8-trimethoxyflavone	31.71	0.35
	MOL000073	Ent-epicatechin	48.96	0.24
	MOL000449	Stigmasterol	43.83	0.76
	MOL001458	Coptisine	30.67	0.86
	MOL001490	Bis[(2S)-2-ethylhexyl] benzene-1,2-dicarboxylate	43.59	0.35
	MOL002879	Diop	43.59	0.39
	MOL002897	Epiberberine	43.09	0.78
	MOL008206	Moslosooflavone	44.09	0.25
	MOL010415	11,13-Eicosadienoic acid, methyl ester	39.28	0.23
	MOL012245	5,7,4′-Trihydroxy-6-methoxyflavanone	36.63	0.27
	MOL012246	5,7,4′-Trihydroxy-8-methoxyflavanone	74.24	0.26
	MOL012266	Rivularin	37.94	0.37
Coptidis rhizoma	MOL001454	Berberine	36.86	0.78
	MOL002894	Berberrubine	35.74	0.73
	MOL002897	Epiberberine	43.09	0.78
	MOL002903	(R)-Canadine	55.37	0.77
	MOL002904	Berlambine	36.68	0.82
	MOL002907	Corchoroside A_qt	104.95	0.78
	MOL000622	Magnograndiolide	63.71	0.19
	MOL000785	Palmatine	64.6	0.65
	MOL000098	Quercetin	46.43	0.28
	MOL001458	Coptisine	30.67	0.86
	MOL002668	Worenine	45.83	0.87

OB: oral bioavailability; DL: drug-likeness.