Methanolic Crude Extract of Hagenia abyssinica Possesses Significant Antidiarrheal Effect: Evidence for In Vivo Antidiarrheal Activity

Table 1

Effects of crude extract of H. abyssinica on castor oil-induced diarrhea.

Group	Onset of diarrhea (min)	Number of wet feces	Number of total feces	% inhibition of defecation
Control	58.50 ± 3.45	7.00 ± 0.73	9.83 ± 0.83	—
Crude 100 mg/kg	102.16 ± 7.79^a3b1	4.00 ± 0.44^a1b1	5.00 ± 0.68^a1b1	42.85
Crude 200 mg/kg	132.33 ± 6.33^a3	3.10 ± 0.22^a2b2	3.72 ± 0.53^a2	55.71
Crude 400 mg/kg	137.16 ± 7.84^a3	1.83 ± 0.21^a3	2.66 ± 0.33^a3	73.85
Loperamide 3 mg/kg	169.33 ± 6.075^a3	1 ± 0.25^a3	2.0 ± 0.21^a3	87.50

Data are expressed as mean ± SEM (n = 6). ^aCompared to negative control. ^bCompared to loperamide 3 mg/kg. ¹, ², and ³. Negative controls received 10 ml/kg distilled water.