Methanolic Crude Extract of Hagenia abyssinica Possesses Significant Antidiarrheal Effect: Evidence for In Vivo Antidiarrheal Activity

Table 3

Effects of crude extract of H. abyssinica on castor oil-induced enteropooling

Dose administered	Mean volume of small intestinal content (g)	% inhibition	Mean weight of small intestinal content (ml)	% inhibition
Control	0.69 ± 0.09	—	0.76 ± 0.01	—
100 mg/kg	0.66 ± 0.04^b3	4.30	0.70 ± 0.02	7.89
200 mg/kg	0.50 ± 0.02^a2b2	27.60	0.57 ± 0.06^a2	25.00
400 mg/kg	0.38 ± 0.02^a3	45.00	0.41 ± 0.02^a3	46.00
Loperamide 3 mg/kg	0.36 ± 0.02^a3	47.80	0.38 ± 0.02^a3	50.00

Data are expressed as mean ± SEM (n = 6). ^aCompared to negative control. ^bCompared to loperamide 3 mg/kg. ¹, ², and ³. Negative controls received 10 ml/kg distilled water.