Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats

Figure 2

Histopathological colonic mucosal sections at different groups contain ten rats (n = 10): sham control mucosa with the intact epithelial surface and crypts ((a)- A, B), TNBS-induced colitis with severe mucosal ulceration, and totally glandular destruction, as well as crypt abscess formation and loss of mucosal architecture (arrow) ((b)- A, B, X100, X400), TNBS colitis treated with Aloe vera extract 200 mg/kg intragastrically shows moderate loss of mucosal architecture, cryptitis (arrow), goblet cell depletion, and muscle thickening ((c)- A, B, X100, X400), TNBS colitis treated with Aloe vera extract 400 mg/kg intragastrically shows mild loss of mucosal architecture (arrow), cryptitis, goblet cell depletion, and muscle thickening ((d)- A, B, X100, X400), TNBS colitis plus Aloe vera extract 200 mg/kg rectally shows mild loss of mucosal architecture, cryptitis (arrow), goblet cell depletion, and muscle thickening ((e)- A, B, X100, X400), TNBS colitis plus Aloe vera extract 400 mg/kg rectally shows mild cryptitis, goblet cell depletion (arrow), and muscle thickening ((f)- A, B, X100, X400), and TNBS colitis treated with sulfasalazine ((g)- A, B, X100, X400) with mild glandular destruction (arrow), cryptitis, and goblet cell depletion.

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