Review Article
Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products
Table 1
Medicinal plants acting on the depolarization of ICCs.
| | Medicinal plants or decoctions (reference) | Molecular mechanism |
| | Depolarizers of the pacemaker potential of ICCs | | Gamisoyo-san [14], Citrus unshiu peel extracts [41], Dangkwisoo-san [43] | Via M3 receptor | | Magnolia officinalis [42] | Via M2 and M3 receptors | | Banhasasim-tang [44] | Via M3 and 5-HT3 receptors | | Daegeonjung-tang [45] | Via M3 and 5-HT4 receptors | | Hesperidin, a citrus flavonoid [52] | Via 5-HT4 receptor | | Hwangryunhaedok-tang [46], Samhwangsasim-tang [47], Socheongryong-tang [48] | Via 5-HT3 and 5-HT4 receptor | | Yukgunja-tang [49] | Via ghrelin receptor | | Leejung-tang [90], Sengmek-san [50] | Via PLC pathway | | Pyungwi-san [51] | Via PKC pathway |
| | Inhibitors of the pacemaker potential of ICCs | | Galgeun-tang [26] | Via α2- and β1-adrenoceptors | | Quercetin [91] | Via opioid receptor signaling pathways |
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M receptors: muscarinic acetylcholine receptors; 5-HT receptors: 5-hydroxytryptamine receptors; PLC: phospholipase C; PKC: protein kinase C.
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