Research Article
Gualou Guizhi Granule Suppresses LPS-Induced Inflammatory Response of Microglia and Protects against Microglia-Mediated Neurotoxicity in HT-22 via Akt/NF-κB Signaling Pathways
Figure 10
(a) Conditioned medium from LPS plus GLGZG-treated BV2 microglia cells significantly enhanced cell viability (69.56%, 72.13%, and 86.34%) on HT-22 cells, as compared to the LPS-treated BV2 microglia cell conditioned medium (). Effects of GLGZG on the protein expression of Bcl-2, cleaved caspase-3, and Bax. (b–e) The levels of Bcl-2 notably declined, while cleaved caspase-3 and Bax increased in the LPS-treated BV2 microglia cell conditioned medium. However, GLGZG exhibited a more pronounced effect on Bcl-2, cleaved caspase-3, and Bax expression.
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