Gualou Guizhi Granule Suppresses LPS-Induced Inflammatory Response of Microglia and Protects against Microglia-Mediated Neurotoxicity in HT-22 via Akt/NF-κB Signaling Pathways

Figure 7

GLGZG inhibited the activation of the NF-κB pathway in LPS-activated BV2 microglia. (a, b) GLGZG dose dependently suppressed NF-κBp65 expression in the nucleus compared with the average levels in the LPS group (). (c, d) Effects of GLGZG on the protein expression of regulators of NF-κB in the cytosol. IκBα expression decreased and increased with GLGZG treatment, while p-IκBα and IKKβ expression, respectively, increased and decreased with GLGZG treatment compared to the LPS group ().

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