|
| Symptoms | | Groups | Mean difference between groups (95% CI) | −value |
| Placebo (n = 64) mean ± SD | Garlic (n = 65) mean ± SD |
|
| Mood symptoms | Cycle 0
Cycle 1
Cycle 2
Cycle 3 | 7.43 ± 2.18
6.28 ± 2.21
5.76 ± 2.02
5.18 ± 1.85 | 7.56 ± 2.09
4.95 ± 1.92
3.67 ± 2.03
2.33 ± 1.92 | −0.13 (−0.08–0.61)
1.32 (0.60–2.04)
2.08 (1.37–2.79)
2.84 (2.18–3.50) | 0.727
<0.001
<0.001
<0.001 |
|
| Behavioral symptoms | Cycle 0
Cycle 1
Cycle 2
Cycle 3 | 13.29 ± 4.38
11.73 ± 3.82
10.50 ± 3.48
9.57 ± 3.27 | 13.46 ± 3.87
9.53 ± 4.16
7.24 ± 4.04
5.07 ± 3.58 | −0.16 (−1.60–1.27)
2.19 (0.80–3.58)
3.25 (1.93–4.57)
4.50 (3.30–5.69) | 0.822
0.002
<0.001
<0.001 |
|
| Physical symptoms | Cycle 0
Cycle 1
Cycle 2
Cycle 3 | 5.64 ± 2.52
5.10 ± 2.74
4.54 ± 2.63
4.06 ± 2.43 | 5.50 ± 3.01
3.81 ± 2.24
2.72 ± 2.24
1.93 ± 1.86 | 0.13 (−0.83–1.10)
1.29 (0.43–2.16)
1.82 (0.97–2.67)
2.12 (1.36–2.88) | 0.787
0.004
<0.001
<0.001 |
|
| Interfering symptoms | Cycle 0
Cycle 1
Cycle 2
Cycle 3 | 6.98 ± 2.34
6.26 ± 2.53
5.87 ± 2.32
5.43 ± 2.18 | 7.55 ± 2.03
5.03 ± 2.41
3.18 ± 2.05
1.86 ± 1.77 | −0.56 (−1.33–0.19)
1.23 (0.37–2.09)
2.69 (1.92–3.45)
3.57 (2.88–4.26) | 0.143
0.005
<0.001
<0.001 |
|
| Total symptoms | Cycle 0
Cycle 1
Cycle 2
Cycle 3 | 33.35 ± 7.96
29.39 ± 8.33
26.68 ± 7.58
24.28 ± 7.22 | 34.09 ± 7.31
23.33 ± 7.67
16.83 ± 7.78
11.21 ± 7.17 | −0.74 (−3.99–1.93)
6.05 (3.26–8.84)
9.85 (7.17–12.53)
13.07 (10.55–15.57) | 0.587
<0.001
<0.001
<0.001 |
|
