Endophytic Fungi from Alstonia boonei De Wild and Greenwayodendron suaveolens (Engl. and Diels) Verdc. subsp. Suaveolens Possess Inhibitory Activity against Pneumonia Causing Bacteria
Table 3
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for antibacterial activity of methanolic extracts of endophytic fungi from A. boonei and G. suaveolens against K. pneumoniae, H. influenzae, P. aeruginosa, and E. coli.
Samples
Bacterial strains
Inhibition parameters (g/L)
Antibacterial effects
MIC
MBC
MBC/MIC
GS15
H. influenzae
6.25 × 10−4
2.5 × 10−3
4
Bactericidal
P. aeruginosa
2.5 × 10−3
5 × 10−3
2
Bactericidal
K. pneumoniae
2.5 × 10−3
5 × 10−3
2
Bactericidal
E. coli
5 × 10−3
2 × 10−2
4
Bactericidal
AB24
H. influenzae
2 × 10−2
>2 × 10−2
—
—
P. aeruginosa
2 × 10−2
>2 × 10−2
—
—
K. pneumoniae
2 × 10−2
>2 × 10−2
—
—
E. coli
>2 × 10−2
—
—
—
AB38
H. influenzae
10−2
2 × 10−2
2
Bactericidal
P. aeruginosa
10−2
>2 × 10−2
—
—
K. pneumoniae
10−2
>2 × 10−2
—
—
E. coli
2 × 10−2
>2 × 10−2
—
—
AB83
H. influenzae
2 × 10−2
>2 × 10−2
—
—
P. aeruginosa
2 × 10−2
>2 × 10−2
—
—
K. pneumoniae
2 × 10−2
>2 × 10−2
—
—
E. coli
2 × 10−2
>2 × 10−2
—
—
Levofloxacin®
H. influenzae
78 × 10−7
625 × 10−7
8
Bacteriostatic
P. aeruginosa
25 × 10−5
25 × 10−5
1
Bactericidal
K. pneumoniae
>25 × 10−5
—
—
—
E. coli
>25 × 10−5
—
—
—
AB: Alstonia boonei; GS: Greenwayodendron suaveolens; GS15: methanolic extract of Aspergillus spp. 1; AB24: methanolic extract of Fusarium spp. 1; AB38: methanolic extract of Neoscytalidium spp. 2 and AB83: methanolic extract of Acremonium spp. 2; —: not determined.
