Research Article
Acute and Subchronic Toxicological Evaluation of the Herbal Product HAD-B1 in Rats
Table 5
Biochemical values of rats treated with HAD-B1 for 13-week period.
| | Group (mg/kg) | TP (g/dL) | ALB (g/dL) | A/G ratio | T-BIL (mg/dL) | ALP (U/L) | AST (U/L) | ALT (U/L) | CREA (mg/dL) | BUN (mg/dL) | T-CHO (mg/dL) | TG (mg/dL) | GLU (mg/dL) | CA (mg/dL) | IP (mg/dL) | CK (U/L) | Na (mmol/L) | K (mmol/L) | Cl (mmol/L) |
| | Male | G1 (0) | Mean | 5.9 | 3.8 | 1.8 | 0.03 | 279.9 | 97.7 | 36.0 | 0.5 | 17.8 | 64.3 | 26.2 | 170.4 | 9.1 | 5.7 | 273.3 | 146.0 | 4.37 | 106.9 | | SD | 0.3 | 0.1 | 0.1 | 0.01 | 42.3 | 19.2 | 3.6 | 0.0 | 3.4 | 19.8 | 7.8 | 22.1 | 0.3 | 0.4 | 215.8 | 0.7 | 0.39 | 1.2 | | G2 (500) | Mean | 5.8 | 3.8 | 1.9 | 0.03∗ | 274.3 | 93.3 | 33.9 | 0.5 | 16.2 | 56.4 | 37.5 | 169.8 | 9.1 | 5.7 | 304.9 | 146.2 | 4.53 | 106.9 | | SD | 0.2 | 0.1 | 0.1 | 0.02 | 30.8 | 15.3 | 4.5 | 0.1 | 2.5 | 11.3 | 14.1 | 23.1 | 0.3 | 0.6 | 176.4 | 1.2 | 0.38 | 1.5 | | G3 (1000) | Mean | 6.8 | 4.4 | 1.9 | 0.1 | 147.5 | 125.4 | 44.7 | 0.6 | 20.8 | 78.4 | 18.3 | 143.8 | 9.7 | 4.5 | 449.9 | 145.0 | 4.1 | 107.4 | | SD | 0.6 | 0.4 | 0.1 | 0.0 | 50.6 | 38.8 | 22.3 | 0.1 | 4.4 | 24.9 | 8.2 | 12.6 | 0.6 | 1.2 | 326.5 | 1.2 | 0.4 | 2.9 | | G4 (2000) | Mean | 6.7 | 4.4 | 2.0 | 0.1 | 133.3 | 113.9 | 38.5 | 0.5 | 19.5 | 75.7 | 21.3 | 143.7 | 9.7 | 4.8 | 377.3 | 145.2 | 4.1 | 107.2 | | SD | 0.5 | 0.4 | 0.1 | 0.0 | 21.2 | 76.6 | 23.8 | 0.0 | 1.7 | 23.0 | 9.1 | 13.1 | 0.4 | 0.9 | 257.1 | 0.8 | 0.5 | 1.9 |
| | Female | G1 (0) | Mean | 6.5 | 4.3 | 2.0 | 0.1 | 137.9 | 108.3 | 39.3 | 0.5 | 19.7 | 75.9 | 15.6 | 148.5 | 9.6 | 4.6 | 261.7 | 145.2 | 4.1 | 107.4 | | SD | 0.5 | 0.4 | 0.2 | 0.0 | 38.5 | 36.6 | 16.4 | 0.0 | 2.8 | 18.8 | 5.7 | 17.5 | 0.4 | 1.0 | 240.2 | 1.6 | 0.3 | 1.8 | | G2 (500) | Mean | 6.4 | 4.2 | 1.9 | 0.1 | 185.1 | 102.5 | 33.9 | 0.5 | 18.7 | 67.3 | 17.9 | 145.6 | 9.4 | 4.7 | 283.9 | 145.4 | 4.1 | 107.1 | | SD | 0.3 | 0.2 | 0.1 | 0.0 | 45.3 | 22.5 | 7.9 | 0.0 | 2.7 | 11.6 | 6.3 | 18.4 | 0.2 | 0.9 | 152.3 | 0.6 | 0.2 | 1.2 | | G3 (1000) | Mean | 6.8 | 4.4 | 1.9 | 0.1 | 147.5 | 125.4 | 44.7 | 0.6 | 20.8 | 78.4 | 18.3 | 143.8 | 9.7 | 4.5 | 449.9 | 145.0 | 4.1 | 107.4 | | SD | 0.6 | 0.4 | 0.1 | 0.0 | 50.6 | 38.8 | 22.3 | 0.1 | 4.4 | 24.9 | 8.2 | 12.6 | 0.6 | 1.2 | 326.5 | 1.2 | 0.4 | 2.9 | | G4 (2000) | Mean | 6.7 | 4.4 | 2.0 | 0.1 | 133.3 | 113.9 | 38.5 | 0.5 | 19.5 | 75.7 | 21.3 | 143.7 | 9.7 | 4.8 | 377.3 | 145.2 | 4.1 | 107.2 | | SD | 0.5 | 0.4 | 0.1 | 0.0 | 21.2 | 76.6 | 23.8 | 0.0 | 1.7 | 23.0 | 9.1 | 13.1 | 0.4 | 0.9 | 257.1 | 0.8 | 0.5 | 1.9 |
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Number of animals: 10; SD: standard deviation. Significant difference as compared with control, . |
