Research Article
Acute and Subchronic Toxicological Evaluation of the Herbal Product HAD-B1 in Rats
Table 6
Biochemical values of rats for 4-week recovery.
| | Group (mg/kg) | TP (g/dL) | ALB (g/dL) | A/G ratio | T-BIL (mg/dL) | ALP (U/L) | AST (U/L) | ALT (U/L) | CREA (mg/dL) | BUN (mg/dL) | T-CHO (mg/dL) | TG (mg/dL) | GLU (mg/dL) | CA (mg/dL) | IP (mg/dL) | CK (U/L) | Na (mmol/L) | K (mmol/L) | Cl (mmol/L) |
| | Male | G1 (0) | Mean | 5.8 | 3.7 | 1.8 | 0.04 | 248.2 | 117.0 | 46.0 | 0.5 | 13.1 | 58.0 | 25.8 | 158.6 | 8.7 | 4.8 | 275.2 | 146.5 | 4.4 | 107.1 | | SD | 0.2 | 0.1 | 0.2 | 0.01 | 11.8 | 25.6 | 6.2 | 0.1 | 0.7 | 6.4 | 8.1 | 13.2 | 0.2 | 0.2 | 163.8 | 0.4 | 0.3 | 1.0 | | G4 (2000) | Mean | 5.8 | 3.7 | 1.8 | 0.01 | 208.2 | 87.4 | 34.0 | 0.4 | 12.0 | 56.8 | 28.8 | 175.6 | 8.8 | 5.0 | 190.6 | 145.6 | 4.3 | 106.2 | | SD | 0.3 | 0.2 | 0.1 | 0.01 | 34.3 | 12.7 | 2.8 | 0.1 | 1.1 | 13.2 | 12.4 | 12.2 | 0.2 | 0.4 | 120.8 | 1.1 | 0.3 | 1.6 |
| | Female | G1 (0) | Mean | 6.3 | 4.1 | 1.9 | 0.03 | 119.0 | 87.6 | 37.6 | 0.5 | 17.2 | 62.0 | 18.2 | 178.2 | 9.2 | 4.8 | 186.4 | 146.7 | 4.5 | 107.5 | | SD | 0.2 | 0.1 | 0.2 | 0.01 | 14.7 | 4.8 | 7.0 | 0.0 | 1.6 | 6.4 | 5.8 | 17.1 | 0.1 | 0.4 | 46.0 | 1.6 | 0.3 | 0.6 | | G4 (2000) | Mean | 6.4 | 4.3 | 2.1 | 0.06 | 124.6 | 87.2 | 42.8 | 0.5 | 14.8 | 68.4 | 20.8 | 173.0 | 9.0 | 4.5 | 180.2 | 146.7 | 4.1 | 107.6 | | SD | 0.2 | 0.1 | 0.1 | 0.02 | 12.3 | 16.7 | 25.4 | 0.1 | 2.3 | 10.4 | 7.6 | 18.5 | 0.3 | 0.5 | 66.0 | 0.7 | 0.3 | 1.5 |
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Number of animals: 5; SD: standard deviation. Significant difference as compared with control, . |
