Research Article
Acute and Subchronic Toxicological Evaluation of the Herbal Product HAD-B1 in Rats
Table 7
Histopathological findings of rats treated with HAD-B1 for 13-week period.
| Organ | N | Histological findings | Male | Female | G1 | G4 | G1 | G4 |
| Liver | 10 | Inflammatory cell foci | Minimal, multifocal | 2 | 2 | 0 | 1 | Kidney | 10 | Tubular basophilia | Minimal, multifocal | 3 | 2 | 0 | 0 | Minimal, focal | 0 | 1 | 0 | 0 | Slight, multifocal | 0 | 1 | 0 | 0 | Tubular casts | Present | 1 | 0 | 0 | 0 | Cortical scar | Present | 1 | 0 | 2 | 0 | Medullary mineralization | Minimal, multifocal | 1 | 0 | 2 | 0 | Adrenal gland | 10 | Cortical vacuolation | Minimal, diffuse | 2 | 2 | 0 | 0 | Lung | 10 | Inflammatory cell infiltration, perivascular | Minimal, multifocal | 2 | 0 | 0 | 0 | Prostate gland | | Inflammatory cell infiltration, interstitial | | | — | — | Minimal, multifocal | 2 | 1 | Slight, multifocal | 0 | 1 | Concretion | | | Minimal, multifocal | 1 | 0 | Testis | 10 | Bilateral tubular atrophy | | | — | — | Severe, diffuse | 0 | 1∗ | Epididymis | 10 | Oligospermia, bilateral | | | — | — | Moderate, diffuse | 0 | 1 | Thyroid gland | 10 | Ultimobranchial cysts | | | | | Present | 1 | 0 | 0 | 0 | Mammary gland | 10 | Adenocarcinoma | — | — | | | Present | | | 1∗∗ | 0 |
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—: not applicable; : reduced testis at necropsy; : mass on the right mammary gland at necropsy. |