Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated from Hyptidendron canum

Figure 2

Leishmanicidal and cytotoxic activity. Promastigote forms of L. (L.) infantum were incubated with different concentrations of maslinic acid (a), miltefosine (b), or amphotericin B (c) for 24 h; in each of these treatments, the effective concentrations 50% (EC₅₀) were estimated. In addition, peritoneal macrophages from golden hamsters were also incubated with maslinic acid (d), miltefosine (e), or amphotericin B (f) for 24 h, and the cytotoxic concentration 50% (CC₅₀) was calculated. These experiments were repeated three times, and the values are represented as mean ± standard deviation.

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