Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated from Hyptidendron canum

Figure 3

Anti-amastigote activity of maslinic acid. Peritoneal macrophages from golden hamsters were isolated and infected with promastigote forms of L. (L.) infantum at 10 : 1 ratio. Twenty-four hours later, infected macrophages were treated with different concentrations of maslinic acid (a), miltefosine (b), and amphotericin B (c). Infected cells were incubated with the drugs for 24 h and their infection indexes were estimated, as well as the effective concentration 50% for each treatment. indicates a significant difference concerning the control group.

(a)

(b)

(c)