Research Article

Investigating the Multitarget Pharmacological Mechanism of Ursolic Acid Acting on Colon Cancer: A Network Pharmacology Approach

Table 2

The top 20 significant enriched KEGG pathways for intersection target.

Description valueCountGene ID

TNF signaling pathway1.68E−1619MAPK3/PTGS2/TNF/MMP3/RELA/FOS/MMP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/ICAM1/IL1B/CREB1/SELE/ATF2/CSF2
AGE-RAGE signaling pathway in diabetic complications3.75E−1618MAPK3/TNF/MMP2/RELA/STAT3/VEGFA/CCND1/BCL2/BAX/JUN/IL6/CASP3/MAPK8/ICAM1/IL1B/SELE/NOS3/CDK4
Human cytomegalovirus infection7.12E−1624MAPK3/PTGER2/PTGS2/PTGER4/TNF/MDM2/RELA/STAT3/VEGFA/CCND1/CDKN1A/BAX/CASP9/IL6/CASP3/NFKBIA/CASP8/IL1B/CREB1/PRKCG/ATF2/FASLG/CDK4/CDK6
Hepatitis B1.09E−1521MAPK3/TNF/RELA/STAT3/BCL2/FOS/CDKN1A/BAX/CASP9/MMP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/CREB1/PRKCG/ATF2/BIRC5/FASLG
Kaposi sarcoma-associated herpesvirus infection3.32E−1522MAPK3/PTGS2/RELA/STAT3/VEGFA/CCND1/FOS/CDKN1A/BAX/CASP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/ICAM1/CREB1/CSF2/CDK4/CDK6/FGF2
IL-17 signaling pathway4.70E−1416MAPK3/PTGS2/TNF/MMP3/MMP1/RELA/FOS/MMP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/IL1B/CSF2
Measles1.51E−1318RELA/STAT3/CCND1/BCL2/BCL2L1/FOS/BAX/CASP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/IL1B/FASLG/CDK4/CDK6
Apoptosis1.38E−1217MAPK3/TNF/CTSB/RELA/BCL2/BCL2L1/FOS/BAX/CASP9/JUN/CASP3/MAPK8/NFKBIA/CASP8/MCL1/BIRC5/FASLG
Prostate cancer2.09E−1114AR/MAPK3/SRD5A2/MMP3/MDM2/PLAU/RELA/CCND1/BCL2/CDKN1A/CASP9/MMP9/NFKBIA/CREB1
Endocrine resistance2.41E−1114MAPK3/ESR2/ESR1/MMP2/MDM2/CCND1/BCL2/FOS/CDKN1A/BAX/MMP9/JUN/MAPK8/CDK4
Human T-cell leukemia virus 1 infection4.25E−1119POLB/TERT/MAPK3/TNF/RELA/CCND1/BCL2L1/FOS/CDKN1A/BAX/JUN/IL6/MAPK8/NFKBIA/ICAM1/CREB1/ATF2/CSF2/CDK4
Epstein-Barr virus infection9.41E−1118TNF/MDM2/RELA/STAT3/CCND1/BCL2/CDKN1A/BAX/CASP9/JUN/IL6/CASP3/MAPK8/NFKBIA/CASP8/ICAM1/CDK4/CDK6
Platinum drug resistance1.29E−1012TOP2A/MAPK3/MDM2/BCL2/BCL2L1/CDKN1A/BAX/CASP9/CASP3/CASP8/BIRC5/FASLG
Small cell lung cancer1.51E−1013NOS2/PTGS2/RELA/CCND1/BCL2/BCL2L1/CDKN1A/BAX/CASP9/CASP3/NFKBIA/CDK4/CDK6
Hepatitis C1.55E−1016NR1H3/PPARA/MAPK3/TNF/RELA/STAT3/CCND1/CDKN1A/BAX/CASP9/CASP3/NFKBIA/CASP8/FASLG/CDK4/CDK6
Pancreatic cancer2.11E−1012MAPK3/RELA/STAT3/VEGFA/CCND1/BCL2L1/CDKN1A/BAX/CASP9/MAPK8/CDK4/CDK6
Relaxin signaling pathway1.03E−0914MAPK3/NOS2/MMP1/MMP2/RELA/VEGFA/FOS/MMP9/JUN/MAPK8/NFKBIA/CREB1/ATF2/NOS3
Toxoplasmosis1.85E−0913MAPK3/NOS2/ALOX5/TNF/RELA/STAT3/BCL2/BCL2L1/CASP9/CASP3/MAPK8/NFKBIA/CASP8
Bladder cancer2.00E−099MAPK3/MMP1/MMP2/MDM2/VEGFA/CCND1/CDKN1A/MMP9/CDK4
p53 signaling pathway2.10E−0911MDM2/CCND1/BCL2/BCL2L1/CDKN1A/BAX/CASP9/CASP3/CASP8/CDK4/CDK6