Study on the Absorption of Arsenic Species in Realgar Based on the Form and Valence

Figure 1

Reductive-oxidative methylation metabolic pathway of arsenic. AsV is first reduced to AsIII under the action of glutathione (GSH). AsIII is converted to MMAV after catalysis by methyltransferase (AS3MT), at the same time S-adenosylmethionine (SAM) and GSH providing methyl donors. MMAV is converted to MMAIII under the action of GSH, and MMAIII is secondary methylated to DMAV under the action of AS3MT, SAM, and GSH.