Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Table 2

Effect of HEAc and VBS on oxidative parameters in the cortex of mice evaluated in the posttreatment experiment of antidepressant-like activity.

Treatments	GSH	LPO	SOD	CAT
N	36.97 ± 3.62	1.85 ± 0.03	43.23 ± 2.93	3.71 ± 2.69
Veh	21.94 ± 0.84^a	1.85 ± 0.08	68.22 ± 2.18	6.89 ± 1.38
Flu	26.33 ± 2.84^a	2.00 ± 0.06	41.75 ± 3.28^a	3.91 ± 1.71
HEAc 30	36.39 ± 1.87^b	2.02 ± 0.03	38.87 ± 3.05^a	2.70 ± 1.02
HEAc 300	30.90 ± 1.24^b	1.75 ± 0.08	64.40 ± 3.57	6.74 ± 0.29
VBS	30.81 ± 2.38^b	1.94 ± 0.02	53.52 ± 2.43^a	8.31 ± 1.58

Note. N, naive; Veh, (vehicle, water); Flu, fluoxetine (30 mg/kg) hydroalcoholic extract of Aloysia citriodora (HEAc, 30 or 300 mg/kg); VBS, verbascoside (30 mg/kg). ANOVA (one way) (n = 8), post hoc Tuckey. ^a compared to the N group (naive group). ^bcompared to the Veh group (vehicle group). Reduced glutathione (GSH; μg/mg tissue); lipid hydroperoxide (LPO, μm/MDA/g); SOD (superoxide dismutase, U/mg protein); CAT (catalase, μmol H₂O₂/min).