Neutrophils: As a Key Bridge between Inflammation and Thrombosis

Figure 1

When pathogens invade the body, a small number of pathogens will be cleared by neutrophils and the body will return to normal. However, when the pathogen invading the body exceeds the clearance capacity of neutrophils, the formation of neutrophil lysis and the release of NET occur. NET activates platelets, endothelial cells, coagulation factors, and damages the body’s anticoagulation and fibrinolysis systems, making the body in a hypercoagulable state. Activated neutrophils can also interact with activated platelets, endothelial cells, coagulation factors, anticoagulant, and fibrinolytic factors to further accelerate thrombosis and eventually lead to immune thrombosis.