Xiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism
Table 3
Differential metabolites in viral pneumonia model mice induced by poly (I:C) after the treatment of XCH.
No.
Formula
RT (min)
m/z
Metabolites
VIP
FC
Trend
Pathway
M vs. C
X vs. M
M vs. C
X vs. M
M vs. C
X vs. M
1
C6H8O6
1.65
175.02
Ascorbic acid
1.44
1.71
0.64
1.30
↓
↑
2
C6H13O9P
1.42
259.02
D-glucose 6-phosphate
1.94
1.44
1.95
0.68
↑
↓
c
3
C5H13NO
1.33
104.11
Choline
1.46
1.84
0.65
1.50
↓
↑
4
C10H16N2O3S
5.35
245.10
Biotin
1.91
2.27
0.47
1.79
↓
↑
g
5
C6H13O9P
1.53
259.02
D-mannose 6-phosphate
1.87
1.62
0.73
1.36
↓
↑
b
6
C4H9N3O2
1.41
132.08
Creatine
1.53
1.44
0.68
1.32
↓
↑
d
7
C6H13NO5
1.43
180.09
D-glucosamine
2.12
1.24
0.47
1.17
↓
↑
b
8
C6H11NO2
1.15
130.09
L-pipecolate
2.09
2.10
0.60
1.53
↓
↑
9
C2H7NO2S
1.35
110.03
Hypotaurine
1.71
1.55
0.68
1.32
↓
↑
f
10
C8H8O4
5.08
167.03
Homogentisic acid
1.55
1.07
1.95
1.33
↑
↑
a
11
C7H6O4
5.64
153.02
Gentisic acid
2.34
1.30
0.41
1.73
↓
↑
a
12
C24H40O5
6.61
407.28
Cholic acid
1.15
1.91
1.14
0.17
↑
↓
13
C21H30O5
5.59
363.22
Hydrocortisone
1.64
1.69
0.54
1.91
↓
↑
e
14
C21H28O5
5.85
361.20
Cortisone
1.76
1.24
0.58
1.46
↓
↑
e
15
C9H13NO3
5.56
184.10
L-adrenaline
1.20
2.37
0.62
1.27
↓
↑
a
16
C4H7N3O
1.38
114.07
Creatinine
1.72
1.30
1.16
0.66
↑
↓
17
C6H12N2O3
1.44
161.09
D-Ala-D-Ala
2.04
1.34
1.68
0.38
↑
↓
18
C5H9NO3
1.35
132.07
Hydroxyproline
1.49
1.41
1.43
0.42
↑
↓
d
19
C10H7NO3
5.38
190.05
Kynurenic acid
2.00
1.18
0.45
0.60
↓
↓
20
C5H7NO3
6.39
130.05
Pyroglutamic acid
1.99
1.43
0.34
0.57
↓
↓
21
C21H30O4
6.25
347.22
Corticosterone
1.48
1.45
1.57
0.53
↑
↓
e
22
C26H45NO7S
7.72
516.30
Taurocholic acid
1.69
2.05
0.25
1.87
↓
↑
f
23
C20H30O4
7.37
333.21
Prostaglandin A2
1.82
1.21
1.32
1.56
↑
↑
24
C20H40O2
11.56
311.30
Arachidic acid
1.69
1.69
1.40
0.26
↑
↓
25
C16H30O2
7.85
255.23
Palmitoleic acid
1.48
1.62
0.62
0.87
↓
↓
Control, model, and XCH high-dose groups (n = 6 per group). RT: retention time; VIP: variable importance of projection; FC: fold change;: as compared to the control group; : as compared to the control group; : as compared to the model group; : as compared to the model group; ↑: content increased; ↓: content decreased; vs.: versus; C: control group; M: model group; X: XCH high-dose group; a: tyrosine metabolism; b: amino sugar and nucleotide sugar metabolism; c: starch and sucrose metabolism; d: arginine and proline metabolism; e: steroid hormone biosynthesis; f: taurine and hypotaurine metabolism; g: biotin metabolism.
